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Winolip EZ Tablet 10pcs
The combination of Bempedoic Acid and Ezetimibe is utilized, along with diet and other cholesterol-lowering medications like statins, to address high blood cholesterol levels. It is specifically employed for the treatment of primary hyperlipidemia in patients diagnosed with heterozygous familial hypercholesterolemia (HeFH) and individuals with heart disease requiring further reduction of their LDL (bad cholesterol) levels.
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✅ Description:
Winolip EZ Tablet is a combination medication prescribed for the treatment of high cholesterol levels. It consists of two active ingredients - Bempedoic Acid (180mg) and Ezetimibe (10mg). Here's an overview:
- Used in adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease.
- Given as an adjunct to diet and maximally tolerated statin therapy for additional lowering of LDL-C.
Bempedoic Acid (180mg):
- Inhibits ATP citrate lyase, an enzyme involved in cholesterol synthesis in the liver.
- Reduces cholesterol production in the liver, leading to decreased LDL cholesterol levels.
Ezetimibe (10mg):
- Blocks cholesterol absorption from the small intestine.
- Promotes the synthesis of low-density lipoprotein (LDL) receptors, reducing serum LDL cholesterol levels.
Administer orally once daily with or without food.
- The safety and effectiveness of pediatric patients have not been established.
- Inform your doctor about any known allergies or if you're taking other medications.
- Disclose pre-existing medical conditions, pregnancy, or breastfeeding.
- Regular monitoring may be needed to assess the medication's safety and efficacy.
- Take the medicine for the prescribed duration even if symptoms improve.
- Abruptly stopping the medication may lead to symptom recurrence.
Always follow your doctor's instructions and report any persistent or worsening side effects.
Safety Advices
Alcohol
UNSAFE
It is not known whether it is safe to consume alcohol with Winolip EZ Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Winolip EZ tablets may be unsafe during pregnancy. Consult your doctor before using this medication during pregnancy. Your doctor will assess the potential risks and benefits before prescribing.
Breastfeeding
CONSULT YOUR DOCTOR
Winolip EZ Tablet may be unsafe during breastfeeding. Consult your doctor before using this medication while breastfeeding. Limited data suggests potential harm to the baby through breast milk.
Driving
CAUTION
It is not known whether the Winolip EZ Tablet affects the ability to drive. Do not drive if you experience symptoms that may affect concentration and reaction time. Consult your doctor for guidance.
Kidney
CONSULT YOUR DOCTOR
Winolip EZ Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended; however, use it under medical supervision.
Liver
CONSULT YOUR DOCTOR
Limited information is available on the use of Winolip EZ Tablet in patients with liver disease. Consult your doctor before using this medication if you have liver disease. Your doctor will evaluate the suitability and potential risks.
✔️ Uses of Winolip EZ Tablet
- Treatment of High Cholesterol
✔️ How does Winolip EZ Tablet work?
Winolip EZ Tablet is a combination of two different medications (Bempedoic acid + Ezetimibe) used to lower cholesterol levels. Here's how each component works:
Bempedoic Acid:
- Inhibits an enzyme called ATP citrate lyase.
- ATP citrate lyase is involved in cholesterol synthesis in the liver.
- By inhibiting this enzyme, Bempedoic acid reduces cholesterol production in the liver.
Ezetimibe:
- Blocks the absorption of cholesterol from the small intestine.
- Reduces the overall delivery of cholesterol to the liver.
- Promotes the synthesis of low-density lipoprotein (LDL) receptors.
Combination Effect:
- Bempedoic acid and Ezetimibe, when used together, provide a dual mechanism of action.
- By inhibiting cholesterol synthesis in the liver and reducing cholesterol absorption from the intestine, the combination lowers overall cholesterol levels in the body.
✔️ Side Effects of Winolip EZ Tablet
- Upper respiratory tract infection
- Muscle spasms
- Hyperuricemia
- Back pain
- Abdominal pain or discomfort
- Bronchitis
- Pain in extremity
- Anemia
- Elevated liver enzymes
✔️ Quick Suggestions:
- Take Bempedoic acid after a meal or with a snack to avoid gastrointestinal problems.
- Inform your doctor if you experience fatigue, muscle weakness, or muscle or joint pain.
- Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform them if you notice signs of liver problems, such as stomach pain, unusually dark urine, yellowing skin, or eyes.
- Lifestyle changes, like a low-fat and salt diet, exercise, not smoking, and cutting down on the amount of alcohol you normally drink, may help this medication work better.
✔️ Indications:
Winolip EZ180mg + 10mg is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.
✔️ Pharmacology
- Bempedoic Acid:
- Acts as an adenosine triphosphate-citrate lyase (ACL) inhibitor.
- Lowers LDL-C by inhibiting cholesterol synthesis in the liver.
- Upregulates low-density lipoprotein receptors, resulting in decreased cholesterol synthesis and lower LDL-C levels.
- Ezetimibe:
- Inhibits cholesterol absorption, reducing overall cholesterol delivery to the liver.
- Promotes the synthesis of LDL receptors, leading to a subsequent reduction of serum LDL-C.
✔️ Dosage & Administration of Winolip EZ Tablet
Administer Bempedoic Acid 180 mg & Ezetimibe 10 mg tablet orally once daily with or without food. The safety and effectiveness of this tablet have not been established in pediatric patients.
✔️ Interaction
- Simvastatin: Avoid concomitant use with simvastatin greater than 20 mg.
- Pravastatin: Avoid concomitant use with pravastatin greater than 40 mg.
✔️ Contraindications
Contraindicated in patients with a known hypersensitivity to ezetimibe tablets.
✔️ Pregnancy & Lactation
Discontinue Bempedoic Acid & Ezetimibe when pregnancy is recognized unless the benefits of therapy outweigh the potential risk to the fetus. Breastfeeding is not recommended during treatment.
✔️ Precautions & Warnings
- Monitor uric acid levels periodically.
- Assess for signs and symptoms of hyperuricemia.
- Discontinue at the first sign of tendon rupture.
- Avoid in patients with a history of tendon disorders or tendon rupture.
✔️ Storage Conditions
Do not store above 30°C temperature. Keep away from light and out of the reach of children.
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here information is for informational purposes only.
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lab tests, medicines, all possible side effects, drug interactions,
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and discuss all your queries related to any disease or medicine. We
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